E-ISSN 2146-9369 | ISSN 2146-3158
 
2025, Vol: 15, Issue: 1
15 / 1Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Review Article 


The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.

Irene Lorinda Indalao, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, Ririn Ramadhany.


Cited By:2

Abstract
Alpha one anti-trypsin (A1AT) is a major serine protease inhibitor found circulating in human blood. A1AT related studies mainly focus on A1AT potential biomarker as well as therapeutic target in non-infectious diseases. Their findings indicate A1AT beneficial features may also be applied for monitoring and treating infectious disease. However, only a few studies have reviewed A1AT 's useful properties as a biomarker and therapeutic agent for infectious diseases. This narrative review aims to summarize growing evidences that support the idea of utilizing A1AT as a tool for monitoring and therapy for infectious diseases.
A1AT showed potential as a biomarker for a wide spectrum of infectious disease, from virus, bacteria, to parasite. Its level and functionality were proposed to predict risk for disease susceptibility or progression and to indicate response therapy. As promising therapeutic agent in various infectious diseases, the administration of A1AT has shown antimicrobial activity, immunomodulatory and anti-apoptotic effect, in addition to more familiar function, suppressing excessive proteolysis.
The broad utilization of A1AT, both as biomarker and therapeutic agent, in studies on infectious diseases seems promising. However, there are issues need to be investigated further before establishing its feasibility as a monitoring and therapy tool against infection diseases. J Microbiol Infect Dis 2019; 9(1): 51-58.

Key words: Alpha-1 anti-trypsin, virus, bacteria, biomarker, drug, infection, parasite, protozoa, review


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Irene Lorinda Indalao
Articles by Agustiningsih Agustiningsih
Articles by Kartika Dewi Puspa
Articles by Eka Pratiwi
Articles by Hartanti Dian Ikawati
Articles by Ririn Ramadhany
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Indalao IL, Agustiningsih A, Puspa KD, Pratiwi E, Ikawati HD, Ramadhany R. The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. J Microbiol Infect Dis. 2019; 9(1): 51-58 . doi:10.5799/jmid.537178

Web Style

Indalao IL, Agustiningsih A, Puspa KD, Pratiwi E, Ikawati HD, Ramadhany R. The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. https://www.jmidonline.org/?mno=302657385 [Access: April 23, 2025]. doi:10.5799/jmid.537178

AMA (American Medical Association) Style

Indalao IL, Agustiningsih A, Puspa KD, Pratiwi E, Ikawati HD, Ramadhany R. The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. J Microbiol Infect Dis. 2019; 9(1): 51-58 . doi:10.5799/jmid.537178


Vancouver/ICMJE Style

Indalao IL, Agustiningsih A, Puspa KD, Pratiwi E, Ikawati HD, Ramadhany R. The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. J Microbiol Infect Dis. (2019), [cited April 23, 2025]; 9(1): 51-58 . doi:10.5799/jmid.537178


Harvard Style

Indalao, I. L., Agustiningsih, . A., Puspa, . K. D., Pratiwi, . E., Ikawati, . H. D. & Ramadhany, . R. (2019) The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. J Microbiol Infect Dis, 9 (1), 51-58 . doi:10.5799/jmid.537178


Turabian Style

Indalao, Irene Lorinda, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, and Ririn Ramadhany. 2019. The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. Journal of Microbiology and Infectious Diseases, 9 (1), 51-58 . doi:10.5799/jmid.537178


Chicago Style

Indalao, Irene Lorinda, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, and Ririn Ramadhany. "The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.." Journal of Microbiology and Infectious Diseases 9 (2019), 51-58 . doi:10.5799/jmid.537178


MLA (The Modern Language Association) Style

Indalao, Irene Lorinda, Agustiningsih Agustiningsih, Kartika Dewi Puspa, Eka Pratiwi, Hartanti Dian Ikawati, and Ririn Ramadhany. "The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.." Journal of Microbiology and Infectious Diseases 9.1 (2019), 51-58 . Print. doi:10.5799/jmid.537178


APA (American Psychological Association) Style

Indalao, I. L., Agustiningsih, . A., Puspa, . K. D., Pratiwi, . E., Ikawati, . H. D. & Ramadhany, . R. (2019) The Utilization of Alpha 1 Anti-trypsin (A1AT) in Infectious Disease Monitoring and Treatment.. Journal of Microbiology and Infectious Diseases, 9 (1), 51-58 . doi:10.5799/jmid.537178


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya