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2025, Vol: 15, Issue: 1
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Case Report 


Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection

Shrijit Nair, Rosa Miquel, Wayel Jassem Al Mohammad, Abid Suddle, Anita Verma.


Abstract
Invasive fungal infection (IFI) with Magnusiomyces capitatus is rare, occurring mainly in patients with hematological diseases. We report first case of tissue invasive M. capitatus infection in a liver transplant recipient (LTR) and use of an IFI biomarker beta-D glucan (BDG) for monitoring antifungal therapy.
A 59 year old male received 3rd liver transplant (LT) for primary sclerosing cholangitis and developed invasive tissue disease due to M. capitatus. BDG was done weekly to monitor the antifungal therapy. However in the 5th week there was sudden rise in BDG >523pg/ml despite dual antifungal. This was used as a guide to investigate for further persistence of focus for IFI and source control. M. capitatus was intermediate resistant to voriconazole and echinocandins. Voriconazole was stopped and LAmB was continued for 6 month. In our experience, biomarker BDG is proved helpful for diagnosis, monitoring the therapeutic efficacy and used as guide to decide the duration of antifungal therapy. J Microbiol Infect Dis 2020; 10(2):98-102.

Key words: Beta D Glucan, Antifungal, M. capitatus


 
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How to Cite this Article
Pubmed Style

Nair S, Miquel R, Mohammad WJA, Suddle A, Verma A. Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. J Microbiol Infect Dis. 2020; 10(2): 98-102 . doi:10.5799/jmid.748721

Web Style

Nair S, Miquel R, Mohammad WJA, Suddle A, Verma A. Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. https://www.jmidonline.org/?mno=302657355 [Access: April 22, 2025]. doi:10.5799/jmid.748721

AMA (American Medical Association) Style

Nair S, Miquel R, Mohammad WJA, Suddle A, Verma A. Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. J Microbiol Infect Dis. 2020; 10(2): 98-102 . doi:10.5799/jmid.748721


Vancouver/ICMJE Style

Nair S, Miquel R, Mohammad WJA, Suddle A, Verma A. Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. J Microbiol Infect Dis. (2020), [cited April 22, 2025]; 10(2): 98-102 . doi:10.5799/jmid.748721


Harvard Style

Nair, S., Miquel, . R., Mohammad, . W. J. A., Suddle, . A. & Verma, . A. (2020) Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. J Microbiol Infect Dis, 10 (2), 98-102 . doi:10.5799/jmid.748721


Turabian Style

Nair, Shrijit, Rosa Miquel, Wayel Jassem Al Mohammad, Abid Suddle, and Anita Verma. 2020. Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. Journal of Microbiology and Infectious Diseases, 10 (2), 98-102 . doi:10.5799/jmid.748721


Chicago Style

Nair, Shrijit, Rosa Miquel, Wayel Jassem Al Mohammad, Abid Suddle, and Anita Verma. "Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection." Journal of Microbiology and Infectious Diseases 10 (2020), 98-102 . doi:10.5799/jmid.748721


MLA (The Modern Language Association) Style

Nair, Shrijit, Rosa Miquel, Wayel Jassem Al Mohammad, Abid Suddle, and Anita Verma. "Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection." Journal of Microbiology and Infectious Diseases 10.2 (2020), 98-102 . Print. doi:10.5799/jmid.748721


APA (American Psychological Association) Style

Nair, S., Miquel, . R., Mohammad, . W. J. A., Suddle, . A. & Verma, . A. (2020) Use of Beta-D-Glucan for Monitoring Antifungal Therapy of a Multidrug Resistant Invasive Magnusiomyces capitatus Infection. Journal of Microbiology and Infectious Diseases, 10 (2), 98-102 . doi:10.5799/jmid.748721


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Journal of Microbiology and Infectious Diseases

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