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Research Article 


Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes

Radhika Murali Iyangar, Ezhilarasan Devaraj, Gopinath Prakasm.


Cited By:14

Abstract
Objective: To evaluate the antimicrobial effect of silymarin and silibinin, a plant derived flavonoid compounds against oral microorganisms that are responsible for dental caries.
Methods: In the current investigation, we analyzed the comparative antibacterial and antifungal effect of silibinin and silymarin against clinical cariogenic oral pathogens through evaluating their minimum inhibitory and minimum bactericidal concentration. We used clinical isolates that are responsible for dental caries and these include Candida albicans, Enterococcus faecalis, Lactobacillus acidophilus, Staphylococcus aureus and Streptococcus mutans to evaluate the anticariogenic potential of silymarin and silibinin.
Results: In the present investigation, silymarin exhibit good antimicrobial effect against most of the oral cariogenic microorganisms tested when compared to silibinin. Interestingly, silymarin shows high sensitivity at a concentration of <5 µg/ml against S. mutans, L. acidophilus and C. albicans. On the other hand, silibinin also have significant antimicrobial effect against the oral pathogens.
Conclusions: Silymarin and silibinin can be used as appropriate drug candidates that control dental caries, endodontic infections. J Microbiol Infect Dis 2017; 7(3):139-143

Key words: silibinin, silymarin, oral infections, oral pathogens


 
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How to Cite this Article
Pubmed Style

Iyangar RM, Devaraj E, Prakasm G. Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. J Microbiol Infect Dis. 2017; 7(3): 139-143.

doi:10.5799/jmid.367545

Web Style

Iyangar RM, Devaraj E, Prakasm G. Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. https://www.jmidonline.org/?mno=302657130 [Access: June 26, 2026].

doi:10.5799/jmid.367545

AMA (American Medical Association) Style

Iyangar RM, Devaraj E, Prakasm G. Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. J Microbiol Infect Dis. 2017; 7(3): 139-143.


doi:10.5799/jmid.367545

Vancouver/ICMJE Style

Iyangar RM, Devaraj E, Prakasm G. Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. J Microbiol Infect Dis. (2017), [cited June 26, 2026]; 7(3): 139-143.


doi:10.5799/jmid.367545

Harvard Style

Iyangar, R. M., Devaraj, . E. & Prakasm, . G. (2017) Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. J Microbiol Infect Dis, 7 (3), 139-143.


doi:10.5799/jmid.367545

Turabian Style

Iyangar, Radhika Murali, Ezhilarasan Devaraj, and Gopinath Prakasm. 2017. Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. Journal of Microbiology and Infectious Diseases, 7 (3), 139-143.


doi:10.5799/jmid.367545

Chicago Style

Iyangar, Radhika Murali, Ezhilarasan Devaraj, and Gopinath Prakasm. "Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes." Journal of Microbiology and Infectious Diseases 7 (2017), 139-143.


doi:10.5799/jmid.367545

MLA (The Modern Language Association) Style

Iyangar, Radhika Murali, Ezhilarasan Devaraj, and Gopinath Prakasm. "Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes." Journal of Microbiology and Infectious Diseases 7.3 (2017), 139-143. Print.


doi:10.5799/jmid.367545

APA (American Psychological Association) Style

Iyangar, R. M., Devaraj, . E. & Prakasm, . G. (2017) Comparative antimicrobial efficacy of silymarin and silibinin against oral microbes. Journal of Microbiology and Infectious Diseases, 7 (3), 139-143.


doi:10.5799/jmid.367545

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