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Research Article 


Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa

Francesca Dickhaus, Mutasim Abu Hasan, Elizabeth Tremblay, Kenneth Klinker, Kenneth Rand, Stacy G. Beal.


Abstract
Objective: Patients ' with cystic fibrosis respiratory systems become colonized with pathogens as early as the first year of life. Some organisms are associated with a decline in pulmonary function and shortened survival, such as a mucoid strain of Pseudomonas aeruginosa (PA).
Methods: We conducted a four year retrospective chart review study examining 158 pediatric and adult cystic fibrosis patients treated at an academic, tertiary care institution to compare patients treated by different antimicrobial regimens.
Results: A higher proportion of mucoid PA study patients received alternate-monthly tobramycin therapy (83.3%), compared to those with non-mucoid PA (62.5%); although a large percentage of patients who had never had a mucoid PA infection were also receiving alternate-monthly tobramycin. Patients who had a mucoid PA infection had more hospitalizations and for longer periods of time than patients who had a non-mucoid PA infection; both mucoid and non-mucoid PA patients were hospitalized more often than patients who had never had a PA infection. We additionally found patients with mucoid PA infections to have strains that were either resistant or had intermediate resistance to tobramycin. Similar trends in resistance were not seen in patients who only received intermittent treatments with tobramycin.
Conclusions Our findings on increased rates of infection with both Aspergillus (in the alternate-monthly inhaled tobramycin group) and NTM (in the overall patient population) comparative to international averages were also interesting, and open the doors to future research regarding CF patients with these infections. J Microbiol Infect Dis 2017; 7(4):178-185

Key words: Cystic fibrosis, Pseudomonas, Tobramycin


 
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How to Cite this Article
Pubmed Style

Dickhaus F, Hasan MA, Tremblay E, Klinker K, Rand K, Beal SG. Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. J Microbiol Infect Dis. 2017; 7(4): 178-185 .

doi:10.5799/jmid.368802

Web Style

Dickhaus F, Hasan MA, Tremblay E, Klinker K, Rand K, Beal SG. Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. https://www.jmidonline.org/?mno=302657038 [Access: June 28, 2026].

doi:10.5799/jmid.368802

AMA (American Medical Association) Style

Dickhaus F, Hasan MA, Tremblay E, Klinker K, Rand K, Beal SG. Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. J Microbiol Infect Dis. 2017; 7(4): 178-185 .


doi:10.5799/jmid.368802

Vancouver/ICMJE Style

Dickhaus F, Hasan MA, Tremblay E, Klinker K, Rand K, Beal SG. Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. J Microbiol Infect Dis. (2017), [cited June 28, 2026]; 7(4): 178-185 .


doi:10.5799/jmid.368802

Harvard Style

Dickhaus, F., Hasan, . M. A., Tremblay, . E., Klinker, . K., Rand, . K. & Beal, . S. G. (2017) Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. J Microbiol Infect Dis, 7 (4), 178-185 .


doi:10.5799/jmid.368802

Turabian Style

Dickhaus, Francesca, Mutasim Abu Hasan, Elizabeth Tremblay, Kenneth Klinker, Kenneth Rand, and Stacy G. Beal. 2017. Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. Journal of Microbiology and Infectious Diseases, 7 (4), 178-185 .


doi:10.5799/jmid.368802

Chicago Style

Dickhaus, Francesca, Mutasim Abu Hasan, Elizabeth Tremblay, Kenneth Klinker, Kenneth Rand, and Stacy G. Beal. "Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa." Journal of Microbiology and Infectious Diseases 7 (2017), 178-185 .


doi:10.5799/jmid.368802

MLA (The Modern Language Association) Style

Dickhaus, Francesca, Mutasim Abu Hasan, Elizabeth Tremblay, Kenneth Klinker, Kenneth Rand, and Stacy G. Beal. "Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa." Journal of Microbiology and Infectious Diseases 7.4 (2017), 178-185 . Print.


doi:10.5799/jmid.368802

APA (American Psychological Association) Style

Dickhaus, F., Hasan, . M. A., Tremblay, . E., Klinker, . K., Rand, . K. & Beal, . S. G. (2017) Clinical and microbiological impact of inhaled tobramycin treatment on cystic fibrosis patients with Pseudomonas aeruginosa. Journal of Microbiology and Infectious Diseases, 7 (4), 178-185 .


doi:10.5799/jmid.368802

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