E-ISSN 2146-9369 | ISSN 2146-3158
 

Review Article


Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus

Kingsley Chukwuemeka Nwachukwu, Ositadinma Chinyere Ugbogu, Ijeoma Linda Nwosu, Ebubechukwu Nwarunma.

Abstract
Quorum sensing (QS) is a communication mechanism utilized by microorganisms to deliberately unleash virulence factors for their survival in living or non-living hosts. Biofilm, one of virulence factors that entrenches pathogenicity is developed through this process. Accumulation of biofilm as a result of heightened quorum sensing effect results in persistent spread of diseases and in extension, antibiotic resistance. Staphylococcus aureus and Pseudomonas aeruginosa are the major causative agents of nosocomial diseases which include wound and skin infections; so many synthetic and natural remedies have been introduced to reduce or entirely eliminate the development of QS-mediated virulence factors through repression of genes that encode them at the molecular level. Therefore, the activities of medicinal plants and chemical agents as inhibitors against QS-mediated virulence factors of P. aeruginosa and S. aureus strains are discussed and compared in this review. Overall, having the knowledge of target sites of plant extracts and chemical inhibitors and their mechanisms in these pathogenic bacterial cells as discussed in the review will assist scientists and medical practitioners in decision making for better therapeutic regimen in the treatment of bacterial diseases.

Key words: Anti-quorum sensing, Medicinal plants, Drugs, Inhibitors


 
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How to Cite this Article
Pubmed Style

Nwachukwu KC, Ugbogu OC, Nwosu IL, Nwarunma E. Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. J Microbiol Infect Dis. 2023; 13(3): 98-109. doi:10.5455/JMID.2023.v13.i3.1


Web Style

Nwachukwu KC, Ugbogu OC, Nwosu IL, Nwarunma E. Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. https://www.jmidonline.org/?mno=302657408 [Access: February 02, 2024]. doi:10.5455/JMID.2023.v13.i3.1


AMA (American Medical Association) Style

Nwachukwu KC, Ugbogu OC, Nwosu IL, Nwarunma E. Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. J Microbiol Infect Dis. 2023; 13(3): 98-109. doi:10.5455/JMID.2023.v13.i3.1



Vancouver/ICMJE Style

Nwachukwu KC, Ugbogu OC, Nwosu IL, Nwarunma E. Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. J Microbiol Infect Dis. (2023), [cited February 02, 2024]; 13(3): 98-109. doi:10.5455/JMID.2023.v13.i3.1



Harvard Style

Nwachukwu, K. C., Ugbogu, . O. C., Nwosu, . I. L. & Nwarunma, . E. (2023) Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. J Microbiol Infect Dis, 13 (3), 98-109. doi:10.5455/JMID.2023.v13.i3.1



Turabian Style

Nwachukwu, Kingsley Chukwuemeka, Ositadinma Chinyere Ugbogu, Ijeoma Linda Nwosu, and Ebubechukwu Nwarunma. 2023. Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. Journal of Microbiology and Infectious Diseases, 13 (3), 98-109. doi:10.5455/JMID.2023.v13.i3.1



Chicago Style

Nwachukwu, Kingsley Chukwuemeka, Ositadinma Chinyere Ugbogu, Ijeoma Linda Nwosu, and Ebubechukwu Nwarunma. "Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus." Journal of Microbiology and Infectious Diseases 13 (2023), 98-109. doi:10.5455/JMID.2023.v13.i3.1



MLA (The Modern Language Association) Style

Nwachukwu, Kingsley Chukwuemeka, Ositadinma Chinyere Ugbogu, Ijeoma Linda Nwosu, and Ebubechukwu Nwarunma. "Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus." Journal of Microbiology and Infectious Diseases 13.3 (2023), 98-109. Print. doi:10.5455/JMID.2023.v13.i3.1



APA (American Psychological Association) Style

Nwachukwu, K. C., Ugbogu, . O. C., Nwosu, . I. L. & Nwarunma, . E. (2023) Anti-quorum sensing effects of medicinal plants and chemical compounds: A new dimension against Pseudomonas aeruginosa and Staphylococcus aureus. Journal of Microbiology and Infectious Diseases, 13 (3), 98-109. doi:10.5455/JMID.2023.v13.i3.1