E-ISSN 2146-9369 | ISSN 2146-3158
 

Research Article 


Clinico-epidemiological profile of Fever of Unknown Origin

Aparna Reddy Panyala, Shravani Reddy Maram.


Abstract
Objectives: Fever of Unknown Origin (FUO) in children remains difficult to diagnose. This prospective, observational study aimed to determine the clinico-etiological profile and the role of clinical procedures in establishing the diagnosis.
Methods: Children (1 month-16 years) with prolonged fever meeting the criteria of FUO were included. A detailed medical history, physical examination and laboratory tests were conducted according to an algorithm (phase I-III). Clinical procedures that were useful in obtaining final etiology were evaluated.
Results: In total, 69 children were enrolled, categorized into five groups based on etiology of FUO. Infections (31.8%) were the leading cause followed by malignancy (20.2%), connective tissue disorder and miscellaneous conditions (14.5%); undiagnosed patients (18.8%) had either a spontaneous resolution or incomplete workup. Duration of fever was 20-60 days, longer in malignancies, least in infections and mean ± SD duration between admission and a definitive diagnosis was 5.65 ± 1.06 days. Tuberculosis was the most common among the infections, systemic onset juvenile idiopathic arthritis and Common acute lymphoblastic leukemia antigen positive B cell acute lymphoblastic leukemia were common causes of connective tissue disorder and malignancy, respectively.
The diagnosis was established by Phase II (33.3%) and Phase III (34.8%) investigations. Non-invasive and invasive investigations were useful in 56.3%, and 43.7 %, respectively.
Conclusions: Infections are the most common cause of FUO in children followed by malignancy. A stepwise approach is useful in diagnosis. Infections and connective tissue disorders are diagnosed by non-invasive investigations while malignancy and miscellaneous conditions by invasive investigations. Focused clinical and diagnostic approach is mandated. J Microbiol Infect Dis 2019; 9(3):137-143.

Key words: Acute lymphoblastic leukemia, algorithm, children, fever of unknown origin, children


 
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Pubmed Style

Aparna Reddy Panyala, Shravani Reddy Maram. Clinico-epidemiological profile of Fever of Unknown Origin. J Microbiol Infect Dis. 2019; 9(4): 137-143 . doi:10.5799/jmid.657846


Web Style

Aparna Reddy Panyala, Shravani Reddy Maram. Clinico-epidemiological profile of Fever of Unknown Origin. https://www.jmidonline.org/?mno=302656967 [Access: October 12, 2024]. doi:10.5799/jmid.657846


AMA (American Medical Association) Style

Aparna Reddy Panyala, Shravani Reddy Maram. Clinico-epidemiological profile of Fever of Unknown Origin. J Microbiol Infect Dis. 2019; 9(4): 137-143 . doi:10.5799/jmid.657846



Vancouver/ICMJE Style

Aparna Reddy Panyala, Shravani Reddy Maram. Clinico-epidemiological profile of Fever of Unknown Origin. J Microbiol Infect Dis. (2019), [cited October 12, 2024]; 9(4): 137-143 . doi:10.5799/jmid.657846



Harvard Style

Aparna Reddy Panyala, Shravani Reddy Maram (2019) Clinico-epidemiological profile of Fever of Unknown Origin. J Microbiol Infect Dis, 9 (4), 137-143 . doi:10.5799/jmid.657846



Turabian Style

Aparna Reddy Panyala, Shravani Reddy Maram. 2019. Clinico-epidemiological profile of Fever of Unknown Origin. Journal of Microbiology and Infectious Diseases, 9 (4), 137-143 . doi:10.5799/jmid.657846



Chicago Style

Aparna Reddy Panyala, Shravani Reddy Maram. "Clinico-epidemiological profile of Fever of Unknown Origin." Journal of Microbiology and Infectious Diseases 9 (2019), 137-143 . doi:10.5799/jmid.657846



MLA (The Modern Language Association) Style

Aparna Reddy Panyala, Shravani Reddy Maram. "Clinico-epidemiological profile of Fever of Unknown Origin." Journal of Microbiology and Infectious Diseases 9.4 (2019), 137-143 . Print. doi:10.5799/jmid.657846



APA (American Psychological Association) Style

Aparna Reddy Panyala, Shravani Reddy Maram (2019) Clinico-epidemiological profile of Fever of Unknown Origin. Journal of Microbiology and Infectious Diseases, 9 (4), 137-143 . doi:10.5799/jmid.657846