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Research Article 


Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults

Anil Chander, Chandrika Devi Shrestha.


Cited By:11

Abstract
Objectives: There are contradictory reports about the use of adenosine deaminase (ADA) as a diagnostic marker in tuberculous peritonitis patients. Reports evaluating significance of ADA activity in the diagnosis of tuberculous peritonitis in adults are lacking in Nepal. We thus set out to investigate the ascitic fluid ADA levels in suspected tuberculous peritonitis patients and to determine the diagnostic significance of the test statistically.
Materials and Methods: This study population comprised of two different adult patients groups. Group I - 35 suspected cases of tuberculous peritonitis and Group II - 35 cases of transudative ascites - the control group (patients with biochemically proved transudates or hypoproteinaemia) and peritoneal tap was done. ADA estimation was carried out by spectrophotometry.
Results: ADA levels (Mean ± SD) in suspected tuberculous peritonitis and transudative ascites cases were 48.5 ± 17.9 U/L and 19.8 ± 7.7 U/L respectively (P<0.001). In the receiver operating characteristic (ROC) curve for ascites, ADA cut-off level of 41.5 U/L was found to yield the best results of differential diagnosis; sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the test in tuberculous peritonitis cases were 80.0%, 97.2 %, 96.6%, 82.9%, 88.6% respectively.
Conclusion: ADA levels are elevated in suspected tuberculous peritonitis cases and it is a simple, rapid, inexpensive and the least invasive test. It is thus a useful biochemical marker for the early diagnosis of tuberculous peritonitis while waiting for the results of mycobacterial cultures or biopsies.


 
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Pubmed Style

Anil Chander, Chandrika Devi Shrestha. Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. J Microbiol Infect Dis. 2013; 3(3): 104-108 . doi:10.5799/jmid2013.03.0091


Web Style

Anil Chander, Chandrika Devi Shrestha. Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. https://www.jmidonline.org/?mno=302656965 [Access: October 12, 2024]. doi:10.5799/jmid2013.03.0091


AMA (American Medical Association) Style

Anil Chander, Chandrika Devi Shrestha. Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. J Microbiol Infect Dis. 2013; 3(3): 104-108 . doi:10.5799/jmid2013.03.0091



Vancouver/ICMJE Style

Anil Chander, Chandrika Devi Shrestha. Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. J Microbiol Infect Dis. (2013), [cited October 12, 2024]; 3(3): 104-108 . doi:10.5799/jmid2013.03.0091



Harvard Style

Anil Chander, Chandrika Devi Shrestha (2013) Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. J Microbiol Infect Dis, 3 (3), 104-108 . doi:10.5799/jmid2013.03.0091



Turabian Style

Anil Chander, Chandrika Devi Shrestha. 2013. Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. Journal of Microbiology and Infectious Diseases, 3 (3), 104-108 . doi:10.5799/jmid2013.03.0091



Chicago Style

Anil Chander, Chandrika Devi Shrestha. "Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults." Journal of Microbiology and Infectious Diseases 3 (2013), 104-108 . doi:10.5799/jmid2013.03.0091



MLA (The Modern Language Association) Style

Anil Chander, Chandrika Devi Shrestha. "Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults." Journal of Microbiology and Infectious Diseases 3.3 (2013), 104-108 . Print. doi:10.5799/jmid2013.03.0091



APA (American Psychological Association) Style

Anil Chander, Chandrika Devi Shrestha (2013) Diagnostic significance of ascites adenosine deaminase levels in suspected tuberculous peritonitis in adults. Journal of Microbiology and Infectious Diseases, 3 (3), 104-108 . doi:10.5799/jmid2013.03.0091