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Abstract - Evaluation of Antibody Levels After Vaccination (Sinovac-CoronaVac) in Healthcare Workers
Hatice Erdogan, Filiz Pehlivanoglu, Gonul Sengoz, Feride Velaei

Evaluation of Antibody Levels After Vaccination (Sinovac-CoronaVac) in Healthcare Workers

Hatice Erdogan1, Filiz Pehlivanoglu2, Gönül Sengöz2, Feride Velaei1

1University of Health Sciences, Haseki Training and Research Hospital, Clinic of Medical Microbiology, Istanbul, Turkey

2University of Health Sciences, Haseki Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

ABSTRACT

Objectives: This study aims to evaluate the effectiveness of the inactivated SARS-COV-2 vaccine (Sinovac-CoronaVac), first administered to healthcare professionals in Turkey on January 14, 2021.

Methods: Healthcare professionals without a history of COVID-19, PCR test positivity, or chronic disease were included in the study. The antibody levels for S1 RBD antigen were measured with the Siemens SARS-CoV-2 IgG (sCOVG) kit one month and six months after the two-dose CoronaVac vaccine.

Results: A total of 108 health professionals, 35 women and 73 men, were included in this study. The mean age of the participants was 37.5 ± 10.7 years. A total of 103 (95.3%) individuals had positive antibody values, and five (4.6%) had negative values after the second vaccination. After the second vaccine dose, 11 (10.1%) participants were diagnosed with COVID-19. There was a significant decrease in antibody values in the sixth month compared to the first month (p <0.001). The first-month measurements showed a significant negative correlation between age and antibody levels. Likewise, there were no significant differences in antibody levels between men and women in the first and sixth months. However, there was a significant difference in antibody levels in the first month for occupational groups (p=0.015). The nurses' antibody levels in the first month were significantly higher than the doctors (p=0.05).

Conclusion: Although the antibody level of the CoronaVac vaccine decreased significantly for the first six months, the infection was mild in 10 % of the participants. Large-scale studies are needed for the protectiveness of vaccines and the prevention of COVID-19.  J Microbiol Infect Dis 2022; 12(4):154-159.

Keywords: COVID-19, healthcare professionals, vaccination 

Volume 12, Number 04 (2022)