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Abstract - Spondylodiscitis by Aspergillus nidulans: A Diagnostic Challenge
Sara Rebelo Casanova, Rita Paulino, Joana Tavares, Ana Cláudia Miranda, Raquel Sabino, Cristina Veríssimo, Cristina Toscano, Kamal Mansinho

Spondylodiscitis by Aspergillus nidulans: A Diagnostic Challenge

Sara Rebelo Casanova1, Rita Paulino2, Joana Tavares3, Ana Cláudia Miranda1, Raquel Sabino4, Cristina Veríssimo4, Cristina Toscano2, Kamal Mansinho1

 

1Infectious Diseases Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal

2Laboratory of clinical microbiology and molecular biology, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal

3Neurosurgery Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal

4Department of Infectious Diseases/ Reference Unit for Parasitic and Fungal Infections, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal

 

ABSTRACT

Fungal infections are significant causes of morbidity and mortality in immunocompromised patients. Aspergillus spondylodiscitis is an uncommon manifestation of invasive aspergillosis and a significant cause of death and frailty.

We report a case of spondylodiscitis caused by Aspergillus nidulans section in an HIV patient with Burkitt's lymphoma, who presented with long-term lower back pain and weakness of the lower limbs. Initial MR imaging missed the lesion. Emergent decompression surgery was performed. Fungal culture on the vertebral disc revealed the agent that was later confirmed by sequencing the ITS region of ribosomal DNA genes. Voriconazole was the chosen treatment, and the patient improved. This case demonstrates how difficult a diagnosis can be if we are not considering it.  J Microbiol Infect Dis 2021; 11(3): 162-165.

Keywords: Aspergillus nidulans section, Spondylodiscitis, Voriconazole  

Volume 11, Number 03 (2021)