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Abstract - Recurrence of SARS-CoV-2 RNA among Positive Covid-19 Cases
Amresh Kumar Singh, Ankur Kumar, Vivek Gaur, Indra Prasad Adhikari, Raj Kishore Singh

Recurrence of SARS-CoV-2 RNA among Positive Covid-19 Cases

Amresh Kumar Singh1, Ankur Kumar2, Vivek Gaur2, Indra Prasad Adhikari3, Raj Kishore Singh4

1Department of Microbiology, Baba Raghav Das Medical College Gorakhpur, Uttar Pradesh, India

2Viral Diagnostic Research Laboratory, Department of Microbiology, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India

3Department of Biochemistry, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India

4Covid-19 Ward, Department of Medicine, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India

 

ABSTRACT

Coronavirus disease 2019 (Covid-19) is a highly infectious disease, and its replication decreasing rapidly after the first week, while some level of immunity is built up. A small proportion of discharged patients may become positive again for severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) RNA, even if they meet the discharge criteria. Re-infection of SARS-CoV-2 is an apparently uncommon entity and only a few case reports or case series have been reported from across the whole world. Herein, we have reported two rare Covid-19 cases with recurrence of positive SARS-CoV-2 RNA after a complete clinical cure. The first case was redetected with Covid-19 with more severity after a gap of approximately three weeks after cure, and the second case has recurred after approximately seven weeks with a complication of pulmonary thromboembolism. We report here, the first few cases of a more vigorous Covid-19 recurrence with SARS-CoV-2 RNA in India. J Microbiol Infect Dis 2021; 11(2):108-114.

Keywords: COVID-19, SARS-CoV-2, RT-PCR, recurrence, Re-infection 

Volume 11, Number 02 (2021)